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Enzyme Replacement Therapy With Agalsidase Alfa in Patients With Fabrys Disease: An Analysis of Registry Data Lancet 374:1986-1996, 1950, Mehta,A.,et al, 2009 See this aricle in Pubmed Article Abstract By comparison with historical natural history data for patients with Fabry�s disease who were not treated with enzyme replacement therapy, long-term treatment with agalsidase alfa leads to substantial and sustained clinical benefits.

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